Regulatory T cells are suppressive T cells that control immune homeostasis and prevent autoimmunity. However, they are also highly active in cancer.
If the tumor microenvironment is so metabolically desolate, why do regulatory T cells thrive there?
In this project, we use highly specialized reporter and mutant mice to study regulatory T cells in the tumor microenvironment. Single-cell analyses of metabolic function, Seahorse analysis, epigenetic and transcriptional profiling, and miniaturized assays of suppressive function are used in the lab.