Three new publications!

We're starting off 2018 strong with three new publications in the Delgoffe Lab!

Check out a new review by Dayana and Greg in Clinical Cancer ResearchAntitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy.

It was a long time coming, but Menk & Scharping et al published in Cell ReportsEarly TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

And the newest pub (which came out today!) by Menk et al in the Journal of Experimental Medicine: 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Go check out our new research, and congrats to all the lab members involved!

Recap - F99 Fellows meeting at the NCI

 The 2017 F99 Fellows cohort

The 2017 F99 Fellows cohort

Fourth year graduate student Nicole Scharping, pictured above among other graduate students who received the F99 fellowship grant from the National Cancer Institute (NCI), recently attended a F99 Fellows meeting in Bethesda, MD. During this two day meeting, the fellows were able to meet and learn about one another's research, as well as learn about choosing post-doctoral mentors, careers in cancer research, and tour the NIH. 

Delgoffe Lab @ SITC 2017!

 The Delgoffe lab, rocking the "lumberjack scientist" look.

The Delgoffe lab, rocking the "lumberjack scientist" look.

The Delgoffe lab is psyched to be attending and presenting at the Society for Immunotherapy of Cancer (SITC) 32nd Annual Meeting in National Harbor, MD!

Two of our lab members are giving talks at SITC 2017 on Friday in Concurrent Session 108: Energizing Immune Cell Metabolism in Cancer:

  • Greg M. Delgoffe @ 5:45 – 6:05p - Metabolic Changes in Tumor Microenvironment
  • McLane (Mac) Watson @ 6:20 – 6:35p - Lactic Acid as a Mediator of Metabolic Symbiosis Between Regulatory T cells and the Tumor Microenvironment

Three additional lab members are presenting during the poster sessions:

  • Ashley Menk - 4-1BB costimulation enables PD-1 blockade therapy by inducing T cell mitochondrial function and biogenesis - P152
  • Dayana Rivadeneira - A novel metabolic therapeutic that harnesses the anti-tumor immune responseP484
  • Nicole Scharping - Immunometabolic requirements for T cell exhaustionP156

Come check out our research to learn more about T cell metabolism and immunotherapy in the tumor microenvironment!

New funding in the Delgoffe lab

Our lab is thrilled to to announce that we recently received two grants from the NIH:

  • Greg Delgoffe received the NIH Director’s New Innovator Award for his grant entitled "Exploring and exploiting metabolic plasticity in regulator T cells".
  • Graduate student Nicole Scharping received the National Cancer Institute Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) for her grant entitled "Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy".

Congratulations all!

Finally, An Update!

Hello internet! Long time, no post! While this blog may have been relegated to the bottom of the to-do list, our science has not - our lab has been busy at both bench and keyboard to both better understand T cell metabolism in the tumor microenvironment. We have had some exciting milestones in the past couple of months, which we will briefly highlight in this post.


Our fearless leader, Dr. Greg Delgoffe, has had the opportunity to share our work at a number of national and international conferences in the past couple of months. He presented “Overcoming metabolic checkpoints to antitumor immunity” at the 9th Cellular Therapy Symposium in Erlangen, Germany, and at the 4th ImmunoTherapy Of Cancer Conference in Prague, Czech Republic. Greg also presented work on T cell metabolism at the American Transplant Congress in Chicago, Illinois and at the Transplantation Science Seminar in Victoria, British Columbia. Congrats, Greg!

New lab members:

While a few lab members have moved on to bigger and better things, we would like to formally welcome Dr. Dayana Rivadeneira (postdoctoral fellow) and McLane (Mac) Watson (graduate student)! Welcome to the lab guys!

New social media:

We are live on Twitter! Follow us @DelgoffeLab for day to day updates on lab news and events. We sign our tweets by hashtagging our initials, so you can see who has been tweeting.

That’s all for now, but not for long!

We have many exciting events coming along the pipeline - stay tuned to this blog or follow us on Twitter for updates!

Lab publishes work using metabolic remodeling to improve immunotherapy

Immunotherapy is likely hampered by a metabolically restrictive tumor microenvironment. This week in Cancer Immunology Research, our paper went live describing a role for the type II diabetes drug metformin as a metabolic remodeling agent that enables effective immunotherapy in mouse models!