Much like a desert, the tumor microenvironment is an inhospitable environment for an infiltrating cytotoxic T cell. T cells work to kill tumor cells in the tumor microenvironment, but do not have adequate fuel to function. But what if we could bolster T cells to be better equipped to fight in a poor metabolite environment?
Our lab is exploring how genetically reprogramming T cells can outfit them to function in a poor metabolite environment. We are currently partnering with industry to translate our findings into readily accessible models for clinical evaluation.