Delgoffe Lab @ SITC 2018!

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The Delgoffe lab is ready for the Society for Immunotherapy of Cancer (SITC) 33rd Annual Meeting in Washington D.C.! The whole gang will be there, and we are presenting!

Four lab members are giving talks at SITC 2018!

  • Nicole Scharping on Friday @ 1:30pm - Chronic T cell activation and metabolic stress promote the exhausted T cell state by inducing epigenetic inflexibility (also poster P207)

  • Greg M. Delgoffe on Friday @ 5:25pm - Enhancement of Oncolytic Virus Immunotherapy Through Vector-Encoded Metabolic Modulation of the Tumor Microenvironment

  • Ashley Menk on Friday @ 6:15pm - Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma (also poster O11)

  • McLane (Mac) Watson on Saturday @5:51pm - Lactic acid metabolically supports the high suppressive function of tumor infiltrating regulatory T cells (also poster O13)

Two additional lab members are presenting during the poster sessions:

  • Dayana Rivadeneira - Fueling antitumor immunity using oncolytic viruses encoding metabolic modulators - P616

  • Yiyang “Steve” Wang - Metabolic reprogramming augments CAR T cell function - P208

And congrats to Dayana Rivadeneira, Nicole Scharping, and Mac Watson for winning Young Investigator Awards!

Come check us out to learn about our latest research in T cell metabolism and immunotherapy in the tumor microenvironment!

Summertime News from the Delgoffe Lab

Happy Summer from the Delgoffe Lab! Here are some highlights from what we've been up to the last few months:

New Funding

  • US Army/Department of Defense Translational Team Science Grant (CA170483 -  PIs Delgoffe, Najjar) - Metabolic Remodeling of the Tumor Microenvironment to Improve the Efficacy of Immunotherapy
  • NIH/NIAID R21AI135367 (PI: Delgoffe) - Illuminating metabolic pathways enabled by early T cell activation
  • NIH/NCI P50CA097190 (Project Leader: Delgoffe) - SPORE in Head and Neck Cancer Project 1: Evaluating and overcoming tumor hypoxia as a metabolic barrier to immunotherapy

And graduate Student Ronal Peralta was awarded funding from the University of Pittsburgh's Autoimmunity and Immunopathology Training Program T32.

 

New students

MSTP student Paolo Vignali and Konstantinos Lontos have officially joined our lab. Welcome!

 

Featured highlight from the lab

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PittMed magazine's Feast to Famine: Denying tumors what they need 

 

And finally, we're enjoying the sunshine!

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Updates from the Delgoffe Lab - Spring '18

Spring is here, bringing many new and exciting changes in the Delgoffe lab! We are happy to announce new funding, presentations at conferences, and new personnel to our lab! 

New funding in the Delgoffe Lab

  • Graduate Student Mac Watson was awarded funding from the University of Pittsburgh's Cancer Immunology Training Program T32.

National/International Presentations

  • Greg Delgoffe presented our lab's work on cancer immunometabolism at the Seventh Annual Tsinghua University-University of Pittsburgh Joint Symposium in Beijing, China.
  • Post doctoral fellow Dayana Rivadeneira presented her work on oncolytic viruses at the Immuno-Oncology Young Investigators’ Forum (IOYIF) in Huston, Texas.
  • Graduate student Nicole Scharping presented her work on the metabolic requirements for effective immunotherapy at the Ammerican Association for Cancer Research (AACR) Annual meeting in Chicago, Illinois.

New personnel

Medical fellow Yiyang "Steve" Wang, technician Nathaniel Flick, and graduate students Kristin DePeaux and Ronal Peralta have all joined the Delgoffe lab. Welcome all!

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Three new publications!

We're starting off 2018 strong with three new publications in the Delgoffe Lab!

Check out a new review by Dayana and Greg in Clinical Cancer ResearchAntitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy.

It was a long time coming, but Menk & Scharping et al published in Cell ReportsEarly TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

And the newest pub (which came out today!) by Menk et al in the Journal of Experimental Medicine: 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Go check out our new research, and congrats to all the lab members involved!

Recap - F99 Fellows meeting at the NCI

 The 2017 F99 Fellows cohort

The 2017 F99 Fellows cohort

Fourth year graduate student Nicole Scharping, pictured above among other graduate students who received the F99 fellowship grant from the National Cancer Institute (NCI), recently attended a F99 Fellows meeting in Bethesda, MD. During this two day meeting, the fellows were able to meet and learn about one another's research, as well as learn about choosing post-doctoral mentors, careers in cancer research, and tour the NIH. 

Delgoffe Lab @ SITC 2017!

 The Delgoffe lab, rocking the "lumberjack scientist" look.

The Delgoffe lab, rocking the "lumberjack scientist" look.

The Delgoffe lab is psyched to be attending and presenting at the Society for Immunotherapy of Cancer (SITC) 32nd Annual Meeting in National Harbor, MD!

Two of our lab members are giving talks at SITC 2017 on Friday in Concurrent Session 108: Energizing Immune Cell Metabolism in Cancer:

  • Greg M. Delgoffe @ 5:45 – 6:05p - Metabolic Changes in Tumor Microenvironment
  • McLane (Mac) Watson @ 6:20 – 6:35p - Lactic Acid as a Mediator of Metabolic Symbiosis Between Regulatory T cells and the Tumor Microenvironment

Three additional lab members are presenting during the poster sessions:

  • Ashley Menk - 4-1BB costimulation enables PD-1 blockade therapy by inducing T cell mitochondrial function and biogenesis - P152
  • Dayana Rivadeneira - A novel metabolic therapeutic that harnesses the anti-tumor immune responseP484
  • Nicole Scharping - Immunometabolic requirements for T cell exhaustionP156

Come check out our research to learn more about T cell metabolism and immunotherapy in the tumor microenvironment!

New funding in the Delgoffe lab

Our lab is thrilled to to announce that we recently received two grants from the NIH:

  • Greg Delgoffe received the NIH Director’s New Innovator Award for his grant entitled "Exploring and exploiting metabolic plasticity in regulator T cells".
  • Graduate student Nicole Scharping received the National Cancer Institute Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) for her grant entitled "Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapy".

Congratulations all!

Finally, An Update!

Hello internet! Long time, no post! While this blog may have been relegated to the bottom of the to-do list, our science has not - our lab has been busy at both bench and keyboard to both better understand T cell metabolism in the tumor microenvironment. We have had some exciting milestones in the past couple of months, which we will briefly highlight in this post.

Presentations:

Our fearless leader, Dr. Greg Delgoffe, has had the opportunity to share our work at a number of national and international conferences in the past couple of months. He presented “Overcoming metabolic checkpoints to antitumor immunity” at the 9th Cellular Therapy Symposium in Erlangen, Germany, and at the 4th ImmunoTherapy Of Cancer Conference in Prague, Czech Republic. Greg also presented work on T cell metabolism at the American Transplant Congress in Chicago, Illinois and at the Transplantation Science Seminar in Victoria, British Columbia. Congrats, Greg!

New lab members:

While a few lab members have moved on to bigger and better things, we would like to formally welcome Dr. Dayana Rivadeneira (postdoctoral fellow) and McLane (Mac) Watson (graduate student)! Welcome to the lab guys!

New social media:

We are live on Twitter! Follow us @DelgoffeLab for day to day updates on lab news and events. We sign our tweets by hashtagging our initials, so you can see who has been tweeting.

That’s all for now, but not for long!

We have many exciting events coming along the pipeline - stay tuned to this blog or follow us on Twitter for updates!